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. 1990 May;416(3):347-50.
doi: 10.1007/BF00392072.

Perfusing pipettes

J M Tang  1 , J Wang, F N Quandt, R S Eisenberg
Affiliations

Perfusing pipettes

J M Tang et al. Pflugers Arch. 1990 May.

Abstract

A simple modification of a patch-clamp set-up allows the fluid in a patch pipette to be changed. The time course of the solution exchange is estimated from the time course of change of the reversal potential of the current through an open Ca2+ activated K+ channel: solution exchange takes less than 1 min. Measurements of the power spectrum of noise show that the modified set-up introduces little excess noise below 1 kHz.

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References

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    1. Proc Natl Acad Sci U S A. 1988 May;85(10):3412-6 - PubMed
    1. J Physiol. 1981 Dec;321:195-210 - PubMed
    1. J Gen Physiol. 1989 Aug;94(2):261-78 - PubMed
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