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. 2013:3:2128.
doi: 10.1038/srep02128.

Hollow microporous organic capsules

Buyi Li  1 , Xinjia Yang, Lingling Xia, Muhammad Irfan Majeed, Bien Tan
Affiliations

Hollow microporous organic capsules

Buyi Li et al. Sci Rep. 2013.

Abstract

Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules. They can be used as storage materials or reaction chambers while supplying the necessary path for the design of controlled uptake/release systems. Herein, the synthesis of HMOCs with high surface area through facile emulsion polymerization and hypercrosslinking reactions, is described. Due to their tailored porous structure, these capsules possessed high drug loading efficiency, zero-order drug release kinetics and are also demonstrated to be used as nanoscale reactors for the prepareation of nanoparticles (NPs) without any external stabilizer. Moreover, owing to their intrinsic biocompatibility and fluorescence, these capsules exhibit promising prospect for biomedical applications.

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Figures

Figure 1
Figure 1. Schematic synthetic route of hollow microporous organic capsules (HMOCs).
Figure 2
Figure 2. TEM images of SiO2@PS core-shell precursors with different DVB contents.
(a) SiO2@PS-0.5% DVB, (b) SiO2@PS-1% DVB, (c) SiO2@PS-2.5% DVB, (d) SiO2@PS-5% DVB, (e) SiO2@PS-10% DVB, (f) SiO2@PS-15% DVB.Styrene is 10 ml. The SiO2 nanoparticles core is 130 nm. The mass of SiO2 nanoparticles is 1.2 g. The scale is 200 nm.
Figure 3
Figure 3. TEM images of HMOCs obtained after hypercrosslinking of SiO2@PS core-shell precursors with different DVB content and etching SiO2 core.
(a) 0.5% - HMOCs, (b) 1% - HMOCs, (c) 2.5% - HMOCs, (d) 5% - HMOCs, (e) 10% - HMOCs, (f) 15% - HMOCs.Styrene is 10 ml with 130 nm hollow cavities. TEM images of HMOCs with different thickness of the shell by varying the dose of styrene in SiO2@PS core-shell precursors, (g) 10% - HMOCs - 2.5 ml, (h) 10% - HMOCs - 5 ml, (i) 10% - HMOCs -10 ml, (j) 10% - HMOCs - 15 ml with 130 nm hollow cavities. TEM image of HMOCs with 200 nm hollow cavities. (k) 10% - HMOCs - 5 ml–200 nm, (l) 10% - HMOCs - 10 ml–200 nm. The mass of SiO2 nanoparticles is 1.2 g. The scale is 200 nm.
Figure 4
Figure 4. (a) Nitrogen sorption isotherms at 77.3 K and (b) pore distribution of pore size calculated using DFT methods (slit pore models, differential pore volumes) of HMOCs with 130 nm hollow cavity.
Figure 5
Figure 5. Drug release profile of (a) 0.5% - HMOCs, (b) 1% - HMOCs, (c) 2.5% - HMOCs, (d) 5% - HMOCs, (e) 10% - HMOCs, (f) 15% - HMOCs.
Red line is fitting line.
Figure 6
Figure 6. (a) TEM image of 10% - HMOCs - 2.5 ml - Fe3O4 NPs;(b) 300 K magnetization isotherms of 10% - HMOCs - 2.5 ml - Fe3O4 NPs, (red line) 10% - HMOCs - 2.5 ml - Fe3O4 NPs after soaked in PBS for 48 h (blue line) and 10% - HMOCs - 2.5 ml - Fe3O4 NPs loaded with drug (green line).
See this image and copyright information in PMC

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