Three new glucosides from a cold-adapted fungal strain Mucor sp

Abstract

Two new naphthaline glucosides, 2-hydroxy-3-methoxy-8-methyl-1-O-β-d-glucopyranosylnaphthaline (1) and 1-hydroxy-3-methoxy-8-methyl-2-O-β-d-glucopyranosylnaphthaline (2), together with one new isocoumarin glucoside, 3-(3,3-dichloro-2-hydroxylpropyl)-6-methoxy-8-O-β-d-glucopyranosyl-1H-isochromen-1-one (3), were isolated from a cold-adapted fungal strain Mucor sp. (No. XJ07027-5). Their structures were characterized by detailed analyses of IR, MS, 1D- and 2D-NMR spectra. Among them, 2 showed moderate cytotoxic activity against five tumor cells (A-549, HL-60, MCF-7, SMMC-7721, and SW480).