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Comment
. 2013 Jul 2;21(7):1067-8.
doi: 10.1016/j.str.2013.06.011.

A zinc lock on GGDEF domain dimerization inhibits E. coli biofilms

Mark Gomelsky  1
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A zinc lock on GGDEF domain dimerization inhibits E. coli biofilms

Mark Gomelsky. Structure. .
Free article

Abstract

In this issue of Structure, Zähringer and colleagues present crystal structures of an important signal transduction enzyme, diguanylate cyclase DgcZ from E. coli. The authors show that zinc ions bound to the CZB domain inhibit enzyme activity and reveal how zinc availability affects biofilm formation.

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