Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jun 18;8(6):e65739.
doi: 10.1371/journal.pone.0065739. Print 2013.

Enhanced Intestinal Motility during Oral Glucose Tolerance Test after Laparoscopic Sleeve Gastrectomy: Preliminary Results Using Cine Magnetic Resonance Imaging

Vo Nguyen Trung  1 , Hiroshi Yamamoto, Akira Furukawa, Tsuyoshi Yamaguchi, Satoshi Murata, Masahiro Yoshimura, Yoko Murakami, Shigetaka Sato, Hideji Otani, Satoshi Ugi, Katsutaro Morino, Hiroshi Maegawa, Tohru Tani
Affiliations

Enhanced Intestinal Motility during Oral Glucose Tolerance Test after Laparoscopic Sleeve Gastrectomy: Preliminary Results Using Cine Magnetic Resonance Imaging

Vo Nguyen Trung et al. PLoS One. .

Abstract

Background: Enhanced secretion of glucagon-like peptide-1 (GLP-1) has been suggested as a possible mechanism underlying the improvement in type 2 diabetes mellitus (T2DM) after laparoscopic sleeve gastrectomy (LSG). However, the reason for enhanced GLP-1 secretion during glucose challenge after LSG remains unclear because LSG does not include intestinal bypass. In this study, we focused on the effects of LSG on GLP-1 secretion and intestinal motility during the oral glucose tolerance test (OGTT) using cine magnetic resonance imaging (MRI) before and 3 months after LSG.

Methods: LSG was performed in 12 obese patients with a body mass index >35 kg/m(2). Six patients had T2DM. OGTT was performed before and 3 months after the surgery. Body weight, hemoglobin A1c (HbA1c), and GLP-1 levels during OGTT were examined, and intestinal motility during OGTT was assessed using cine MRI.

Results: Body weight was significantly decreased after surgery in all the cases. HbA1c was markedly decreased in all the diabetic subjects. In all cases, GLP-1 secretion during OGTT was enhanced and cine MRI showed markedly increased intestinal motility at 15 and 30 min during OGTT after LSG.

Conclusions: LSG leads to accelerated intestinal motility and reduced intestinal transit time, which may be involved in the mechanism underlying enhanced GLP-1 secretion during OGTT after LSG.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

References

    1. Chambers AP, Jessen L, Ryan KK, Sisley S, Wilson-Perez HE, et al. (2011) Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology 141: 950–958. - PMC - PubMed
    1. Chambers AP, Kirchner H, Wilson-Perez HE, Willency JA, Hale JE, et al.. (2013) The effects of vertical sleeve gastrectomy in rodents are ghrelin independent. Gastroenterology 144: 50–52 e55. - PMC - PubMed
    1. Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, et al. (2012) Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med 366: 1567–1576. - PMC - PubMed
    1. Lee WJ, Ser KH, Chong K, Lee YC, Chen SC, et al. (2010) Laparoscopic sleeve gastrectomy for diabetes treatment in nonmorbidly obese patients: efficacy and change of insulin secretion. Surgery 147: 664–669. - PubMed
    1. Mingrone G, Castagneto-Gissey L (2009) Mechanisms of early improvement/resolution of type 2 diabetes after bariatric surgery. Diabetes Metab 35: 518–523. - PubMed

MeSH terms