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Comment
. 2013 Jul 16;110(29):11670-1.
doi: 10.1073/pnas.1310349110. Epub 2013 Jul 3.

Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells

Sidinh Luc  1 , Stuart H Orkin
Affiliations
Comment

Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells

Sidinh Luc et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The molecular targets of MLL in hematopoietic stem and progenitor cells. Five transcription factors were identified to be directly regulated by MLL in hematopoietic stem and progenitor cells. The gene activation of Hoxa9 and Mecom is dependent on the MLL cofactor Menin, whereas Eya1, Pbx1, and Prdm16 are cofactor independent. MLL controls HSC maintenance and proliferation through Prdm16 by regulating cell cycle.
See this image and copyright information in PMC

Comment on

  • An MLL-dependent network sustains hematopoiesis.
    Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EK, Moore AW, Chen Y, Cheng C, Ernst P. Artinger EL, et al. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12000-5. doi: 10.1073/pnas.1301278110. Epub 2013 Jun 6. Proc Natl Acad Sci U S A. 2013. PMID: 23744037 Free PMC article.

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