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. 2013 Sep 6;25(33):4555-60.
doi: 10.1002/adma.201301033. Epub 2013 Jul 4.

Microencapsulation of chemotherapeutics into monodisperse and tunable biodegradable polymers via electrified liquid jets: control of size, shape, and drug release

Pouria Fattahi  1 , Ali Borhan, Mohammad Reza Abidian
Affiliations

Microencapsulation of chemotherapeutics into monodisperse and tunable biodegradable polymers via electrified liquid jets: control of size, shape, and drug release

Pouria Fattahi et al. Adv Mater. .

Abstract

This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.

Keywords: biomaterials; brain tumor; drug delivery; electrojetting; mathematical modeling; microcapsules.

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