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. 2013:1015:311-20.
doi: 10.1007/978-1-62703-435-7_20.

PharmGKB: the Pharmacogenomics Knowledge Base

Caroline F Thorn  1 , Teri E Klein, Russ B Altman
Affiliations

PharmGKB: the Pharmacogenomics Knowledge Base

Caroline F Thorn et al. Methods Mol Biol. 2013.

Abstract

The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. The PharmGKB Web site, http://www.pharmgkb.org , displays genotype, molecular, and clinical knowledge integrated into pathway representations and Very Important Pharmacogene (VIP) summaries with links to additional external resources. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute. Registered users can access and download data to aid in the design of future pharmacogenetics and pharmacogenomics studies.

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Figures

Fig. 1
Fig. 1
The PharmGKB homepage, http://www.pharmgkb.org, contains directed search boxes where users can also browse from lists of genes, variants, drugs, or diseases
Fig. 2
Fig. 2
The TMPT gene page showing genomic variants and related drugs with links to the annotations and haplotypes and tabs for clinical pharmacogenomics, pharmacogenomics research, overview, VIP, haplotypes, pathways, related drugs and diseases, and downloads and links out
Fig. 3
Fig. 3
The Irinotecan Pathway, view of a model human liver cell showing blood, bile, and intestinal compartments, indicating tissue-specific involvement of genes in the irinotecan pathway. Drugs are depicted by purple boxes, transporter genes by turquoise ovals, genes coding for metabolic enzymes by blue ovals. http://www.pharmgkb.org/do/serve?objId=PA2001&objCls=Pathway
See this image and copyright information in PMC

References

    1. NIH. Goals for the PGRN. http://www.nigms.nih.gov/Research/FeaturedPrograms/PGRN/
    1. Altman RB, Klein TE. Challenges for biomedical informatics and pharmacogenomics. Annu Rev Pharmacol Toxicol. 2002;42:113–133. - PubMed
    1. Povey S, et al. The HUGO Gene Nomenclature Committee (HGNC) Hum Genet. 2001;109:678–680. - PubMed
    1. Wishart DS, et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006;34:D668–D672. - PMC - PubMed
    1. Eichelbaum M, et al. New feature: pathways and important genes from PharmGKB. Pharmacogenet Genomics. 2009;19:403. - PMC - PubMed

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