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Review
. 2013 Jul 3;280(1765):20130011.
doi: 10.1098/rspb.2013.0011. Print 2013 Aug 22.

Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs

Osnat Bartok  1 , Charalambos P Kyriacou, Joel Levine, Amita Sehgal, Sebastian Kadener
Affiliations
Review

Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs

Osnat Bartok et al. Proc Biol Sci. .

Abstract

Circadian (24 h) clocks provide a source of internal timing in most living organisms. These clocks keep time by using complex transcriptional/post-translational feedback loops that are strikingly resilient to changes in environmental conditions. In the last few years, interest has increased in the role of post-transcriptional regulation of circadian clock components. Post-transcriptional control plays a prominent role in modulating rapid responses of the circadian system to environmental changes, including light, temperature and general stress and will be the focus of this review.

Keywords: circadian clock; environment; post-transcriptional regulation.

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Figures

Figure 1.
Figure 1.
Schematics of how temperature controls alternative splicing of frequency and period. (a) Control of frq alternative splicing at different temperatures (N. crassa). (b) Control of per alternative splicing at different temperatures (Drosophila melanogaster).
See this image and copyright information in PMC

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