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. 2013 Jun 15;6(7):1409-15.
Print 2013.

HPV frequency in penile carcinoma of Mexican patients: important contribution of HPV16 European variant

Ricardo López-Romero  1 , Candela Iglesias-Chiesa, Brenda Alatorre, Karla Vázquez, Patricia Piña-Sánchez, Isabel Alvarado, Minerva Lazos, Raúl Peralta, Beatriz González-Yebra, Anae Romero, Mauricio Salcedo
Affiliations

HPV frequency in penile carcinoma of Mexican patients: important contribution of HPV16 European variant

Ricardo López-Romero et al. Int J Clin Exp Pathol. .

Abstract

The role of human papillomavirus (HPV) infection in penile carcinoma (PeC) is currently reported and about half of the PeC is associated with HPV16 and 18. We used a PCR-based strategy by using HPV general primers to analyze 86 penile carcinomas paraffin-embedded tissues. Some clinical data, the histological subtype, growth pattern, and differentiation degree were also collected. The amplified fragments were then sequenced to confirm the HPV type and for HPV16/18 variants. DNA samples were also subjected to relative real time PCR for hTERC gene copy number. Some clinical data were also collected. Global HPV frequency was 77.9%. Relative contributions was for HPV16 (85%), 31 (4.4%), 11 (4.4%), 58, 33, 18, and 59 (1.4% each one). Sequence analysis of HPV16 identified European variants and Asian-American (AAb-c) variants in 92% and in 8% of the samples, respectively. Furthermore hTERC gene amplification was observed in only 17% of the cases. Our results suggest that some members of HPV A9 group (represented by HPV16, 58, and 31) are the most frequent among PeC patients studied with an important contribution from HPV16 European variant. The hTERC gene amplification could be poorly related to penile epithelial tissue.

Keywords: HPV; México; penile carcinoma.

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Figures

Figure 1
Figure 1
HPV16 variants in Mexican penile cancer samples.
See this image and copyright information in PMC

References

    1. Parkin DM, Whelan SL, Ferlay J, Thomas DB. Cancer Incidence in Five Continents. Lyon, France: IARC Scientific Publication; 2002. p. 155.
    1. Registro histopatológico de neoplasias en México. México, DF: Secretaría de Salud; 2001. www.dgepi.salud.gob.mx.
    1. Gross G, Pfister H. Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts. Med Microbiol Immunol. 2004 Feb;193:35–44. - PubMed
    1. Van Doornum GJ, Korse CM, Buning-Kager JC, Bonfrer JM, Horenblas S, Taal BG, Dillner J. Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites. Br J Cancer. 2003 Apr 7;88:1095–100. - PMC - PubMed
    1. Carter JJ, Madeleine MM, Shera K, Schwartz SM, Cushing-Haugen KL, Wipf GC, Porter P, Daling JR, McDougall JK, Galloway DA. Human papillomavirus 16 and 18 L1 serology compared across anogenital cancer sites. Cancer Res. 2001 Mar 1;61:1934–40. - PubMed

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