Piecing together the extracellular puzzle
- PMID: 23827672
- DOI: 10.1016/j.cell.2013.06.014
Piecing together the extracellular puzzle
Abstract
Large-scale screens to identify protein interactions typically underperform with eukaryotic extracellular proteins. In this issue, Özkan et al. report development of a high-throughput assay designed specifically for extracellular proteins that uncovers a wealth of new interactions among three protein superfamilies in Drosophila and sets the stage for more extensive screens.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks.Cell. 2013 Jul 3;154(1):228-39. doi: 10.1016/j.cell.2013.06.006. Cell. 2013. PMID: 23827685 Free PMC article.
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