Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity
- PMID: 23827702
- DOI: 10.1016/j.stem.2013.06.012
Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity
Abstract
Pathways that regulate epigenetic control of stem cell identity are critical to the molecular etiology of cancer. In back-to-back articles in Cell and Cell Stem Cell, Song et al. identify miR-22 as both a repressor of TET proteins and a powerful oncogene in the mammary epithelium and hematopoietic system.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.Cell Stem Cell. 2013 Jul 3;13(1):87-101. doi: 10.1016/j.stem.2013.06.003. Cell Stem Cell. 2013. PMID: 23827711 Free PMC article.
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MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.Cell. 2013 Jul 18;154(2):311-324. doi: 10.1016/j.cell.2013.06.026. Epub 2013 Jul 3. Cell. 2013. PMID: 23830207 Free PMC article.
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