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. 2014;20(13):2126-37.
doi: 10.2174/13816128113199990428.

Effects of cannabis on impulsivity: a systematic review of neuroimaging findings

Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E Lang, Stefan Borgwardt  1
Affiliations

Effects of cannabis on impulsivity: a systematic review of neuroimaging findings

Johannes Wrege et al. Curr Pharm Des. 2014.

Abstract

We conducted a systematic review to assess the evidence for specific effects of cannabis on impulsivity, disinhibition and motor control. The review had a specific focus on neuroimaging findings associated with acute and chronic use of the drug and covers literature published up until May 2012. Seventeen studies were identified, of which 13 met the inclusion criteria; three studies investigated acute effects of cannabis (1 fMRI, 2 PET), while six studies investigated non-acute functional effects (4 fMRI, 2 PET), and four studies investigated structural alterations. Functional imaging studies of impulsivity studies suggest that prefrontal blood flow is lower in chronic cannabis users than in controls. Studies of acute administration of THC or marijuana report increased brain metabolism in several brain regions during impulsivity tasks. Structural imaging studies of cannabis users found differences in reduced prefrontal volumes and white matter integrity that might mediate the abnormal impulsivity and mood observed in marijuana users. To address the question whether impulsivity as a trait precedes cannabis consumption or whether cannabis aggravates impulsivity and discontinuation of usage more longitudinal study designs are warranted.

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References

    1. Carmichael ST, Price JL. Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys. J Comp Neurol. 1995;363(4):642–64. - PubMed
    1. Zuurman L, Passier PC, de Kam M, Kleijn HJ, Cohen AF, van Gerven JM. Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers. J Psychopharmacol. 2009;23(6):633–44. - PubMed
    1. Indlekofer F, Piechatzek M, Daamen M , et al. Reduced memory and attention performance in a population-based sample of young adults with a moderate lifetime use of cannabis. ecstasy and alcohol. J Psychopharmacol. 2009;23(5):495–509. - PubMed
    1. Solowij N, Michie PT. Cannabis and cognitive dysfunction: parallels with endophenotypes of schizophrenia?. J Psychiatry Neurosci. 2007;32(1):30–52. - PMC - PubMed
    1. Martin-Santos R, Fagundo AB, Crippa JA , et al. Neuroimaging in cannabis use: a systematic review of the literature. Psychol Med . 2010 Mar;40(3):383–98. - PubMed

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