Clinical pregnancy after uterus transplantation

Abstract

Objective: To present the first clinical pregnancy after uterus transplantation.

Design: Case study.

Setting: Tertiary center.

Patient(s): A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.

Intervention(s): Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.

Main outcome measure(s): Implantation of embryo in an allografted human uterus.

Result(s): The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.

Conclusion(s): We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.

Keywords: Uterus transplantation; clinical pregnancy; uterine factor infertility.