[Lapeyronie's disease]

Abstract

Introduction: Lapeyronie's disease is a common condition affecting 3.4 to 9% of the male population. Knowledge of pathophysiology, natural history, and treatment outcomes can guide the care of patients.

Materials and methods: A literature review was carried out between 1940 and 2012 in Pubmed using the keywords: Lapeyronie's disease, Peyronie's disease (PD), pathophysiology of PD, surgical treatment for PD, medical treatment for PD.

Results: Seventy-five articles were selected, including original articles, reviews, and recommendations in English or French. Few studies available are of level 1 and most of them are of 2b and 3 level of evidence.

Conclusion: The pathophysiology of Lapeyronie's disease is controversial. Medical treatments are ineffective. Surgery should be proposed when the curvature is stabilized, and the treatment of the concavity or convexity depends on the size of the erect penis, its curvature angle and erectile function. Penile implant must be proposed to patients when erectile dysfunction is combined with severe curvature.

Keywords: Chirurgie du pénis; Courbure du pénis; Dysfonction érectile; Erectile dysfunction; Implants péniens; Lapeyronie's disease; Maladie de Lapeyronie; Medical penile surgery; Nesbit; Penile curvature; Penile implant; Penile plicature; TGF-β; Yachia.