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Review
. 2013 Oct 28;340(1):9-21.
doi: 10.1016/j.canlet.2013.06.019. Epub 2013 Jul 2.

Eukaryotic translation initiation factors in cancer development and progression

Rita Spilka  1 , Christina Ernst, Anita Kuldeep Mehta, Johannes Haybaeck
Affiliations
Review

Eukaryotic translation initiation factors in cancer development and progression

Rita Spilka et al. Cancer Lett. .

Abstract

Eukaryotic gene expression is a complicated process primarily regulated at the levels of gene transcription and mRNA translation. The latter involves four main steps: initiation, elongation, termination and recycling. Translation regulation is primarily achieved during initiation which is orchestrated by 12 currently known eukaryotic initiation factors (eIFs). Here, we review the current state of eIF research and present a concise summary of the various eIF subunits. As eIFs turned out to be critically implicated in different oncogenic processes the various eIF members and their contribution to onset and progression of cancer are featured.

Keywords: Cancer; Eukaryotic initiation factors; Translation initiation.

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