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. 2013 Jul 5;3(7):e122.
doi: 10.1038/bcj.2013.21.

Monosomal karyotype in Philadelphia chromosome-negative acute lymphoblastic leukemia

Affiliations

Monosomal karyotype in Philadelphia chromosome-negative acute lymphoblastic leukemia

S S Kenderian et al. Blood Cancer J. .
No abstract available

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Figures

Figure 1
Figure 1
Kaplan–Meier survival curves for 112 patients with Philadelphia chromosome-negative acute lymphoblastic leukemia stratified by the presence (blue curve, median survival 24 months) or absence of monosomal karyotype (red curve, median survival 50 months).

References

    1. Breems DA, Van Putten WL, De Greef GE, Van Zelderen-Bhola SL, Gerssen-Schoorl KB, Mellink CH, et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol. 2008;26:4791–4797. - PubMed
    1. Breems DA, Lowenberg B. Acute myeloid leukemia with monosomal karyotype at the far end of the unfavorable prognostic spectrum. Haematologica. 2011;96:491–493. - PMC - PubMed
    1. Gaillard JB, Chiesa J, Reboul D, Arnaud A, Brun S, Donadio D, et al. Monosomal karyotype routinely defines a poor prognosis subgroup in acute myeloid leukemia and is frequently associated with TP53 deletion. Leuk Lymphoma. 2012;53:336–337. - PubMed
    1. Haferlach C, Alpermann T, Schnittger S, Kern W, Chromik J, Schmid C, et al. Prognostic value of monosomal karyotype in comparison to complex aberrant karyotype in acute myeloid leukemia: a study on 824 cases with aberrant karyotype. Blood. 2012;119:2122–2125. - PubMed
    1. Medeiros BC, Othus M, Fang M, Roulston D, Appelbaum FR. Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood. 2010;116:2224–2228. - PMC - PubMed

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