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Editorial
. 2013 Aug;20(8):974-5.
doi: 10.1038/cdd.2013.57.

Another twist in the on and off affair between cell suicide and inflammation

D L Vaux  1
Affiliations
Editorial

Another twist in the on and off affair between cell suicide and inflammation

D L Vaux. Cell Death Differ. 2013 Aug.
No abstract available

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Figures

Figure 1
Figure 1
When a small amount of DNA is electroporated into the cytoplasm of macrophages (left panel) it is bound by AIM2, which triggers formation of an inflammasome by ASC. This activates caspase 8, which activates caspase 3 leading to the classic changes associated with apoptosis such as cleavage of I-CAD and CAD-mediated degradation of the nuclear DNA. When higher levels of DNA are present (right panel), AIM2 and ASC form an inflammasome much more rapidly, and it activates caspase 1 that processes pro-IL-1β and causes cell death characteristic of pyroptosis. One of the surprising findings of Sagulenko et al. was that ASC can not only bind with procaspase 1 via their CARDs, but can also bind to procaspase 8 via pyrin–DED interactions
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