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Comment
. 2013 Jul 5;113(2):97-9.
doi: 10.1161/CIRCRESAHA.113.301933.

Keep PNUTS in your heart

Francesco S Loffredo  1 , James R Pancoast, Richard T Lee
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Free article
Comment

Keep PNUTS in your heart

Francesco S Loffredo et al. Circ Res. .
Free article

Abstract

Aging is a major factor in many cardiovascular diseases. The molecular factors that regulate age-related changes in cardiac physiology and contribute to the increased cardiovascular risk in the elderly are not fully understood. A study recently published in Nature suggests a specific role for microRNAs (miRNAs) in regulating cardiac aging and function, challenging the concept that aging is an inevitable process in the heart.

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  • MicroRNA-34a regulates cardiac ageing and function.
    Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S. Boon RA, et al. Nature. 2013 Mar 7;495(7439):107-10. doi: 10.1038/nature11919. Epub 2013 Feb 20. Nature. 2013. PMID: 23426265

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