Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Feb;17(2 Suppl 1):S115-9.

C-reactive protein of serum and peritoneal fluid in endometriosis

Maryam Kianpour  1 , Mehdi Nematbakhsh, Sayad Mehdi Ahmadi
Affiliations

C-reactive protein of serum and peritoneal fluid in endometriosis

Maryam Kianpour et al. Iran J Nurs Midwifery Res. 2012 Feb.

Abstract

Background: Endometriosis is defined as the existence of endometrial-like tissue outside the uterus. Diagnosis of endometriosis is a challenging theme. Despite the broad search for innovative laboratory tests and advances in imaging technologies, there are still no easy, non-invasive diagnostic tests available. Due to inflammatory process of endometriosis, still C-reactive protein (CRP) level may be the target of initial screening. The aim of this study was to investigate CRP levels as a marker of inflammatory process in serum and peritoneal fluid of patients with endometriosis.

Materials and methods: In a case control study, 179 patients with endometriosis (N = 90) and without endometriosis (N = 89) were evaluated. The venous blood samples were obtained from all patients before laparoscopy and the peritoneal fluid samples were collected from pelvis before any manipulation. Student's t-test was applied to compare the parameters between two groups.

Findings: There was no significant difference between the CRP serum level in patients with endometriosis and infertile women without endometriosis. There was a significant difference in peritoneal level of CRP between case and control groups (p < 0.05).

Conclusions: The findings suggested that measurement of this marker in patients' serum or plasma cannot be used to diagnose endometriosis. It is further recommended that a combination of different markers might be helpful in this regard that could be studied in future.

Keywords: C-reactive protein; Endometriosis; infertility; inflammation; peritoneal fluid; serum.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
CRP levels in serum and peritoneal from the patients with endometriosis (case) and non‐endometriosis (control) The star (*) indicates significant difference from control group (p <0.05).
See this image and copyright information in PMC

References

    1. Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364(9447):1789–99. - PubMed
    1. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24(2):235–58. - PubMed
    1. Yang WC, Chen HW, Au HK, Chang CW, Huang CT, Yen YH, et al. Serum and endometrial markers. Best Pract Res Clin Obstet Gynaecol. 2004;18(2):305–18. - PubMed
    1. Ulukus M, Cakmak H, Arici A. The role of endometrium in endometriosis. J Soc Gynecol Investig. 2006;13(2 Suppl1):467–76. - PubMed
    1. Meola J, Dentillo DB, Rosa e Silva JC, Ferriani RA, Veiga LC, Paro de Paz CC, et al. Glycodelin expression in the endometrium of healthy women and in the eutopic and ectopic endometrium of women with endometriosis. Fertil Steril. 2009;91(5):1676–80. - PubMed

LinkOut - more resources