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Case Reports
. 2013 Sep;67(9):918-21.
doi: 10.1111/ijcp.12184. Epub 2013 Jul 8.

Baclofen in the treatment of persistent hiccup: a case series

A Mirijello  1 , G Addolorato, C D'Angelo, A Ferrulli, G Vassallo, M Antonelli, L Leggio, R Landolfi
Affiliations
Case Reports

Baclofen in the treatment of persistent hiccup: a case series

A Mirijello et al. Int J Clin Pract. 2013 Sep.

Abstract

Background: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments.

Aim: To test baclofen administration for the treatment of persistent hiccup.

Method: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen.

Results: Hiccup stopped in all patients after a single administration of the drug.

Conclusions: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.

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