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. 2013 Jun;9(6):1289-91.
doi: 10.4161/hv.24182. Epub 2013 Mar 6.

A reverse evidence of rotavirus vaccines impact

Federico Martinón-Torres  1 , Angela Aramburo, Nazareth Martinón-Torres, Miriam Cebey, María Teresa Seoane-Pillado, Lorenzo Redondo-Collazo, Jose Maria Martinón-Sánchez
Affiliations

A reverse evidence of rotavirus vaccines impact

Federico Martinón-Torres et al. Hum Vaccin Immunother. 2013 Jun.

Abstract

In 2010, and due to a quality problem identified in the vaccine manufacture, the rotavirus (RV) vaccination was withheld in Spain during 5 months. Our study aimed to evaluate the impact that this sudden cease had on rotavirus acute gastroenteritis (RAGE) hospitalizations. An increase in RAGE hospitalization was observed in parallel to the drop in vaccine coverage. Here, we report the first reverse evidence of rotavirus vaccine impact.

Keywords: Vaccine effectiveness; gastroenteritis/epidemiology; hospitalization; rotavirus infections/prevention & control; rotavirus vaccines.

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Figures

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Figure 1. Vaccine coverage and rotavirus acute gastroenteritis hospitalization rate per 100,000 children at different age intervals in Galicia (north-west Spain) from June 2003 to July 2012. (*) 22% is the mean RV vaccine coverage for that period. However, for 5 mo within that period, no new batches of vaccine were released into the market, and the coverage estimated for those months was 0–5%.
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