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Comment
. 2013 Jul 9;17(4):163.
doi: 10.1186/cc12758.

The gut-brain axis in the critically ill: is glucagon-like peptide-1 protective in neurocritical care?

Mark P Plummer, Juris J Meier, Adam M Deane
Comment

The gut-brain axis in the critically ill: is glucagon-like peptide-1 protective in neurocritical care?

Mark P Plummer et al. Crit Care. .

Abstract

Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted.

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