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. 2013 Nov;57(9):1300-3.
doi: 10.1093/cid/cit453. Epub 2013 Jul 9.

Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary care medical center

Darowan S Akajagbor  1 , Sharon L Wilson, Kapana D Shere-Wolfe, Paul Dakum, Manhattan E Charurat, Bruce L Gilliam
Affiliations

Higher incidence of acute kidney injury with intravenous colistimethate sodium compared with polymyxin B in critically ill patients at a tertiary care medical center

Darowan S Akajagbor et al. Clin Infect Dis. 2013 Nov.

Abstract

Nephrotoxicity was assessed in 173 critically ill patients receiving intravenous colistin or polymyxin B; it occurred in 60.4% and 41.8%, respectively. Further investigation is necessary to elucidate the reason for the difference in nephrotoxicity observed between the groups and to assess the impact of severity of illness and dosing/administration.

Keywords: AKI; PB; colistimethate sodium; colistin; nephrotoxicity.

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