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Competing interests:The author declares that no competing interests exist.
Figures
Figure 1.
The transcription factor EIN3 is…
Figure 1.
The transcription factor EIN3 is a master regulator of transcription, and acts through…
Figure 1.
The transcription factor EIN3 is a master regulator of transcription, and acts through multiple feedback and feedforward regulatory mechanisms. (A) The plant hormone ethylene increases the activity of EIN3. However, EIN3 in turn promotes the expression of proteins that inhibit the response to ethylene via a feedback loop. (B) EIN3 acts both directly and indirectly to increase the expression of its target genes. The indirect feedforward loop involves increased expression of receptors for another plant hormone, gibberellic acid (GID1B/1C). These in turn activate the transcription factor PIF3, which increases expression of EIN3 target genes. (C) The background image shows wildtype Arabidopsis thaliana (left) alongside plants with mutations in one (middle) or four (right) EIN3 target genes (adapted from Figure 4F from Ecker et al., 2013).
Chang KN, Zhong S, Weirauch MT, Hon G, Pelizzola M, Li H, Huang SS, Schmitz RJ, Urich MA, Kuo D, Nery JR, Qiao H, Yang A, Jamali A, Chen H, Ideker T, Ren B, Bar-Joseph Z, Hughes TR, Ecker JR.Chang KN, et al.Elife. 2013 Jun 11;2:e00675. doi: 10.7554/eLife.00675.Elife. 2013.PMID: 23795294Free PMC article.
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