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Comment
. 2013 Jul 23;110(30):12168-9.
doi: 10.1073/pnas.1310930110. Epub 2013 Jul 10.

Anciently duplicated genes reduce uncertainty in molecular clock estimates

Olga Zhaxybayeva  1
Affiliations
Comment

Anciently duplicated genes reduce uncertainty in molecular clock estimates

Olga Zhaxybayeva. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Illustration of node age assignment in traditional, cross-calibrated, and cross-braced relaxed clock Bayesian analyses. Each panel represents a single step in the analysis. Red circles on phylogenetic tree mark the nodes corresponding to the same diversification event. In a gene family that underwent duplication, the tree will have two such nodes. The depicted probability distribution represents prior information about possible times for the diversification event. In a traditional relaxed clock analysis of a gene family without paralogs, the estimate is selected from the distribution (gray dashed line). In a cross-calibrated analysis of a gene family with paralogs, a diversification event is represented by one prior distribution from which the ages of the two nodes are drawn independently, thus introducing an additional constraint into the posterior age estimates. Under even stricter cross-bracing approach, the two nodes are assigned the same age. Modified from figure S1 in Shih and Matzke (4).
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