Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2013 Oct 1;305(7):F968-9.
doi: 10.1152/ajprenal.00386.2013. Epub 2013 Jul 10.

Aldosterone-dependent trans-activation and epigenetic derepression of ENaC: where is the balance?

Alexander Staruschenko  1
Affiliations
Editorial

Aldosterone-dependent trans-activation and epigenetic derepression of ENaC: where is the balance?

Alexander Staruschenko. Am J Physiol Renal Physiol. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Simplified model for the aldosterone-sensitive regulation of α-epithelial Na+ channel (ENaC) expression. Af9 directly binds +78/+92 of the α-ENaC promoter and recruits Dot1a to this position to basally repress α-ENaC transcription. Aldosterone relieves this repression by dispersing the Dot1a-Af9 complex from the α-ENaC promoter, prompting histone H3 Lys79 hypomethylation that induces α-ENaC transcription. In contrast, Sp1 binding to a +222/+229 cis-element of the α-ENaC promoter contributes significantly as a basal driver of α-ENaC, acting independently from and overcoming the Dot1a-Af9 repressor complex. In addition, aldosterone further enhances Sp1 occupancy of the α-ENaC promoter.
See this image and copyright information in PMC

Comment on

References

    1. Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W. Af17 deficiency increases sodium excretion and decreases blood pressure. J Am Soc Nephrol 22: 1076–1086, 2011 - PMC - PubMed
    1. Dynan WS, Tjian R. Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II. Cell 32: 669–680, 1983 - PubMed
    1. Marin M, Karis A, Visser P, Grosveld F, Philipsen S. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell 89: 619–628, 1997 - PubMed
    1. Reisenauer MR, Anderson M, Huang L, Zhang Z, Zhou Q, Kone BC, Morris AP, Lesage GD, Dryer SE, Zhang W. AF17 competes with AF9 for binding to Dot1a to upregulate transcription of epithelial Na+ channel alpha. J Biol Chem 284: 35659–35669, 2009 - PMC - PubMed
    1. Staruschenko A. Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol 2: 1541–1584, 2012 - PMC - PubMed

MeSH terms

LinkOut - more resources