Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 May;8(2):143-4.
doi: 10.1007/BF00177248.

In vitro activity of 4'-iodo-4'-deoxydoxorubicin on human colo-rectal cancer as measured by a short-term antimetabolic assay

R Villa  1 , N Zaffaroni, F Giuliani, G Colella, O Sanfilippo, R Silvestrini
Affiliations
Comparative Study

In vitro activity of 4'-iodo-4'-deoxydoxorubicin on human colo-rectal cancer as measured by a short-term antimetabolic assay

R Villa et al. Invest New Drugs. 1990 May.

Abstract

A short-term antimetabolic assay based upon the inhibition of incorporation of nucleic acid precursors was used to compare the cytotoxicity of a new halogenated anthracycline, 4'-iodo-4'-deoxydoxorubicin (IDX), with that of its parent compound doxorubicin (DX) on human colo-rectal carcinoma specimens. IDX showed a marked dose-dependent effect, with frequencies of activity consistently greater than those of DX at all concentrations. The minimal dose required to induce a significant antimetabolic effect for IDX was 1/10 that for DX.

PubMed Disclaimer

References

    1. Cancer Res. 1987 Aug 1;47(15):4001-6 - PubMed
    1. Cancer Res. 1985 Dec;45(12 Pt 1):5995-9 - PubMed
    1. Invest New Drugs. 1987;5(3):231-4 - PubMed
    1. Invest New Drugs. 1987;5(3):245-50 - PubMed
    1. Cancer Chemother Rep. 1973 Feb;57(1):11-9 - PubMed

Publication types

MeSH terms

LinkOut - more resources