Review
doi: 10.3747/pdi.2012.00320.
Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?
Affiliations
- PMID: 23843586
- PMCID: PMC3707709
- DOI: 10.3747/pdi.2012.00320
Item in Clipboard
Review
Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?
Perit Dial Int.
2013 Jul-Aug.
Abstract
The concentration or appearance rate of cancer antigen 125 (CA125) in peritoneal dialysis (PD) effluent has been used for many years as a biomarker for mesothelial cell mass in patients on PD. However, this marker has limitations, and emerging evidence has raised doubts as to its significance. This review explores our current understanding of CA125, its prominent role in studies of "biocompatible" PD solutions, and the ongoing uncertainty concerning its interpretation as a measure of mesothelial cell health.
Keywords: CA125; Cancer antigen 125; biocompatibility; biomarkers; mesothelial cell mass; peritonitis.
Comment in
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Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?Perit Dial Int. 2013 Nov-Dec;33(6):715-8. doi: 10.3747/pdi.2013.00223. Perit Dial Int. 2013. PMID: 24335135 Free PMC article. No abstract available.
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Re: Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?Perit Dial Int. 2013 Nov-Dec;33(6):718-9. doi: 10.3747/pdi.2013.00254. Perit Dial Int. 2013. PMID: 24335136 Free PMC article. No abstract available.
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