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Review
. 2013 Jul-Aug;33(4):349-52.
doi: 10.3747/pdi.2012.00320.

Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?

Harpaul Cheema  1 , Joanne M Bargman
Affiliations
Review

Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?

Harpaul Cheema et al. Perit Dial Int. 2013 Jul-Aug.

Abstract

The concentration or appearance rate of cancer antigen 125 (CA125) in peritoneal dialysis (PD) effluent has been used for many years as a biomarker for mesothelial cell mass in patients on PD. However, this marker has limitations, and emerging evidence has raised doubts as to its significance. This review explores our current understanding of CA125, its prominent role in studies of "biocompatible" PD solutions, and the ongoing uncertainty concerning its interpretation as a measure of mesothelial cell health.

Keywords: CA125; Cancer antigen 125; biocompatibility; biomarkers; mesothelial cell mass; peritonitis.

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References

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