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Meta-Analysis
. 2013 Jul 2;8(7):e67083.
doi: 10.1371/journal.pone.0067083. Print 2013.

The use of biatain Ag in hard-to-heal venous leg ulcers: meta-analysis of randomised controlled trials

David Leaper  1 , Christian Münter, Sylvie Meaume, Alessandro Scalise, Nacho Blanes Mompó, Birte Petersen Jakobsen, Finn Gottrup
Affiliations
Meta-Analysis

The use of biatain Ag in hard-to-heal venous leg ulcers: meta-analysis of randomised controlled trials

David Leaper et al. PLoS One. .

Abstract

Background: Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs).

Aim: To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing.

Patients and methods: 685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis.

Results: Biatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002).

Conclusion: The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.

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Conflict of interest statement

Competing Interests: BPJ is an employee of Coloplast A/S, who funded this study. The authors are occasionally used as KOLs for advisory boards at Coloplast A/S. Larix Aps, Denmark conducted the statistical analysis. Trial Form Support Aps, Denmark contributed with medical writing of the manuscript. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Figures

Figure 1
Figure 1. Flow chart of literature search.
Figure 2
Figure 2. Forest plot showing the estimated treatment differences defined by percentage relative reduction.
The solid vertical line represents a treatment difference of zero. The confidence intervals (95%) are illustrated by the length of the horizontal lines. The sizes of the filled circles are adjusted to the size of the corresponding study.
See this image and copyright information in PMC

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