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. 2013 Jun 26;6(6):438-43.
Print 2013.

DNA repair gene XRCC3 Thr241Met polymorphism and glioma risk: a meta-analysis

Bao Zhao  1 , Jingliang Ye, Bin Li, Qiang Ma, Guojun Su, Ruizhang Han
Affiliations

DNA repair gene XRCC3 Thr241Met polymorphism and glioma risk: a meta-analysis

Bao Zhao et al. Int J Clin Exp Med. .

Abstract

Background: The polymorphism of XRCC3 Thr241Met has been indicated to be correlated with glioma susceptibility, but study results are still debatable. The present meta-analysis was performed to investigate the association between XRCC3 Thr241Met polymorphism and glioma.

Methods: A total of 3754 glioma patients and 4849 controls from nine separate studies were involved. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) was assessed by the random-effects model.

Results: The association between XRCC3 Thr241Met polymorphism and glioma was significant in the recessive model (OR = 1.36; 95% CI, 1.02 - 1.82; P = 0.03). In a stratified analysis by the ethnicity, significantly increased risk was detected in Asians (OR = 1.93; 95% CI, 1.18 - 3.17; P = 0.009).

Conclusions: In conclusion, XRCC3 Thr241Met polymorphism was implied to be associated with increased glioma risk. More studies are needed to validate this result.

Keywords: Glioma; XRCC3; meta-analysis; polymorphism.

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Figures

Figure 1
Figure 1
Meta-analysis for the association of glioma risk with XRCC3 Thr241Met polymorphism.
Figure 2
Figure 2
Sensitivity analysis through deletion of one study at a time to reflect the influence of the individual dataset to the pooled ORs.
Figure 3
Figure 3
Funnel plot for the glioma risk with XRCC3 Thr241Met polymorphism.
See this image and copyright information in PMC

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