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Review
. 2013 Nov;32(4):321-39.
doi: 10.3109/10641955.2013.807819. Epub 2013 Jul 11.

MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results

James S Betoni  1 , Kimberly Derr, Matthew C Pahl, Laura Rogers, Corinna L Muller, Roger E Packard, David J Carey, Helena Kuivaniemi, Gerard Tromp
Affiliations
Free article
Review

MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results

James S Betoni et al. Hypertens Pregnancy. 2013 Nov.
Free article

Abstract

Objective: The aim was to identify differences in microRNA expression between patients with and without preeclampsia.

Methods: Microarray-based study was carried out with placental samples.

Results: Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets.

Conclusion: The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.

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