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. 2013 Aug 15;23(16):4552-6.
doi: 10.1016/j.bmcl.2013.06.038. Epub 2013 Jun 24.

Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity

Pascal Dao  1 , Rafika Jarray, Johanne Le Coq, Daniel Lietha, Ali Loukaci, Yves Lepelletier, Réda Hadj-Slimane, Christiane Garbay, Françoise Raynaud, Huixiong Chen
Affiliations

Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity

Pascal Dao et al. Bioorg Med Chem Lett. .

Abstract

We report herein the synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK (focal adhesion kinase) inhibitors and the evaluation of their anti-angiogenic activity on HUVEC cells. Generally, the effects of these compounds on endothelial cells could be correlated with their kinase inhibitory activity. The most efficient compounds displayed inhibition of viability against HUVEC cells in the micromolar range, as observed with TAE-226, which was designed by Novartis Pharma AG. X-ray crystallographic analysis of the co-crystal structure for compound 34 revealed that the mode of interaction with the FAK kinase domain is highly similar to that observed in the complex of TAE-226.

Keywords: Anti-angiogenic activity; Diarylamino-1,3,5-triazines; FAK inhibitors; Synthesis; X-ray structure.

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