Development: Hippo signalling turns the embryo inside out
- PMID: 23845241
- DOI: 10.1016/j.cub.2013.05.064
Development: Hippo signalling turns the embryo inside out
Abstract
Lineage decisions in development are thought to be primarily due to differential activation of transcription factors. However, cell position and subcellular organization of signalling also play a role. New studies of the Hippo pathway in the early mouse embryo show how.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Comment on
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The Hippo pathway member Nf2 is required for inner cell mass specification.Curr Biol. 2013 Jul 8;23(13):1195-201. doi: 10.1016/j.cub.2013.05.044. Epub 2013 Jun 20. Curr Biol. 2013. PMID: 23791728
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Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.Curr Biol. 2013 Jul 8;23(13):1181-94. doi: 10.1016/j.cub.2013.05.014. Epub 2013 Jun 20. Curr Biol. 2013. PMID: 23791731 Free PMC article.
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