Review
doi: 10.6092/1590-8577/1652.
BRCA and pancreatic cancer
Affiliations
- PMID: 23846919
- DOI: 10.6092/1590-8577/1652
Item in Clipboard
Review
BRCA and pancreatic cancer
JOP.
.
Free article
Abstract
Germline mutations in BRCA genes have been associated with pancreatic cancer. Laboratory and clinical data suggest that patients with BRCA mutations may be more responsive to therapy consisting of conventional chemotherapy with a poly(ADP-ribose) polymerase inhibitor (PARPi). The most recent data from the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting will be reviewed (Abstracts #11024 and #TPS4144).
Similar articles
-
BRCA and pancreatic cancer: selection of chemotherapy.JOP. 2012 Mar 10;13(2):180-1. JOP. 2012. PMID: 22406596 Review.
-
Pancreatic cancer: BRCA mutation and personalized treatment.Expert Rev Anticancer Ther. 2015;15(10):1223-31. doi: 10.1586/14737140.2015.1086271. Epub 2015 Sep 7. Expert Rev Anticancer Ther. 2015. PMID: 26402249 Review.
-
PARP-inhibitors in BRCA-associated pancreatic cancer.JOP. 2014 Jul 28;15(4):340-3. doi: 10.6092/1590-8577/2690. JOP. 2014. PMID: 25076338
-
Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy.Fam Cancer. 2012 Mar;11(1):41-7. doi: 10.1007/s10689-011-9483-5. Fam Cancer. 2012. PMID: 21989927
-
Germline BRCA Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic Adenocarcinoma.J Clin Oncol. 2015 Oct 1;33(28):3124-9. doi: 10.1200/JCO.2014.59.7401. Epub 2015 May 4. J Clin Oncol. 2015. PMID: 25940717
Cited by
-
Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes.Cancer. 2021 Dec 1;127(23):4393-4402. doi: 10.1002/cncr.33812. Epub 2021 Aug 5. Cancer. 2021. PMID: 34351646 Free PMC article.
-
Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma.Cancer Cell Int. 2019 Mar 4;19:49. doi: 10.1186/s12935-019-0767-4. eCollection 2019. Cancer Cell Int. 2019. PMID: 30867652 Free PMC article.
-
Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts.Pancreas. 2018 Sep;47(8):924-936. doi: 10.1097/MPA.0000000000001136. Pancreas. 2018. PMID: 30113427 Free PMC article.
-
gDNA enrichment by a transposase-based technology for NGS analysis of the whole sequence of BRCA1, BRCA2, and 9 genes involved in DNA damage repair.J Vis Exp. 2014 Oct 6;(92):e51902. doi: 10.3791/51902. J Vis Exp. 2014. PMID: 25350069 Free PMC article.
-
The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms.Int J Biol Sci. 2016 Jan 27;12(3):273-82. doi: 10.7150/ijbs.14951. eCollection 2016. Int J Biol Sci. 2016. PMID: 26929734 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous
