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Review
. 2013 Jul;27(3):85-9.
doi: 10.1016/j.trre.2013.04.001.

Tofacitinab in renal transplantation

Martin S Zand  1
Affiliations
Review

Tofacitinab in renal transplantation

Martin S Zand. Transplant Rev (Orlando). 2013 Jul.

Abstract

Tofacitinib (tositinib, CP-690,550) is a small molecule inhibitor of Janus associated kinases, primarily JAK3 and JAK2, which inhibits cytokine signaling through the IL-2Rγ chain. In this article, we review the mechanism of action of tofacitinib, and pre-clinical and clinical data regarding its use in solid organ transplantation thus far. It is hoped that tofacitinib may form the basis for calcineurin-free immunosuppression, improving renal function while eliminating calcineurin inhibitor renal toxicity. Current studies suggest that tofacitinib is an effective immunosuppressive agent for renal transplantation, but it's use in current protocols carries an increased risk of CMV, BK, and EBV viral infection, anemia and leukopenia, and post-transplant lymphoproliferative disorder.

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References

    1. Wood KJ, Goto R. Mechanisms of rejection: current perspectives. Transplantation. 2012;93:1–10. - PubMed
    1. Magee CN, Boenisch O, Najafian N. The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2012;12:2588–2600. - PMC - PubMed
    1. McGrath MM, Najafian N. The role of coinhibitory signaling pathways in transplantation and tolerance. Frontiers in immunology. 2012;3:47. - PMC - PubMed
    1. Liao W, Lin JX, Leonard WJ. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Current opinion in immunology. 2011;23:598–604. - PMC - PubMed
    1. Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nature reviews Immunology. 2009;9:480–490. - PMC - PubMed

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