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. 2014 Mar;10(2):171-8.
doi: 10.1016/j.jalz.2013.04.003. Epub 2013 Jul 11.

Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: beyond cognition

Joanne M Hamilton  1 , David P Salmon  2 , Rema Raman  3 , Lawrence A Hansen  4 , Eliezer Masliah  4 , Guerry M Peavy  2 , Douglas Galasko  5
Affiliations

Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: beyond cognition

Joanne M Hamilton et al. Alzheimers Dement. 2014 Mar.

Abstract

Background: The relative contributions of cognitive, motor, and behavioral deficits to the impairment of physical or instrumental activities of daily living (ADLs) may differ in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).

Methods: Multiple linear regression analyses were used to identify the amount of variability in physical self-maintenance and instrumental ADL ratings predicted by cognitive, motor, and behavioral indices separately for patients with autopsy-diagnosed DLB (n = 39) or AD (n = 39).

Results: Motor dysfunction accounted for significant variance in physical ADLs in DLB (R(2) change = 0.17), whereas behavioral (R(2) change = 0.23) and motor dysfunction (R(2) change = 0.13) accounted for significant variance in AD. Motor (R(2) change = 0.32) and cognitive (R(2) change = 0.10) dysfunction accounted for significant variance in instrumental ADLs in DLB, whereas cognitive (R(2) change = 0.36) and behavioral (R(2) change = 0.12) dysfunction accounted for significant variance in AD.

Conclusions: Cognitive, motor, and behavioral deficits contribute differently to ADL changes in DLB and AD. Thus, treatments designed to ameliorate a certain aspect of AD or DLB (e.g., cognitive dysfunction) may have a larger impact on everyday functioning in one disorder than the other.

Keywords: Activities of daily living; Alzheimer's disease; Behavior; Cognition; Dementia with Lewy bodies; Motor function.

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References

    1. Aarsland D, Cummings JL, Larsen JP. Neuropsychiatric differences between Parkinson’s disease with dementia and Alzheimer’s disease. Int J Geriatr Psychiatry. 2001;16:184–91. - PubMed
    1. D’Onofrio G, Sancarlo D, Panza F, Copetti M, Cascavilla L, Paris F, et al. Neuropsychiatric symptoms and functional status in Alzheimer’s disease and vascular dementia patients. Curr Alzheimer Res. 2012;9:759–71. - PubMed
    1. Stout JC, Wyman MF, Johnson SA, Peavy GM, Salmon DP. Frontal behavioral syndromes and functional status in probable Alzheimer disease. Am J Geriatr Psychiatry. 2003;11:683–6. - PubMed
    1. Boyle PA, Malloy PF, Salloway S, Cahn-Weiner DA, Cohen R, Cummings JL. Executive dysfunction and apathy predict functional impairment in Alzheimer disease. Am J Geriatr Psychiatry. 2003;11:214–21. - PubMed
    1. Stern Y, Hesdorffer D, Sano M, Mayeux R. Measurement and prediction of functional capacity in Alzheimer’s disease. Neurology. 1990;40:8–14. - PubMed

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