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Case Reports
. 2013 Sep;51(9):3127-9.
doi: 10.1128/JCM.01377-13. Epub 2013 Jul 12.

Diagnostic implications of inconsistent results obtained with the Xpert MTB/Rif assay in detection of Mycobacterium tuberculosis isolates with an rpoB mutation associated with low-level rifampin resistance

Akos Somoskovi  1 , Vanessa Deggim, Diana Ciardo, Guido V Bloemberg
Affiliations
Case Reports

Diagnostic implications of inconsistent results obtained with the Xpert MTB/Rif assay in detection of Mycobacterium tuberculosis isolates with an rpoB mutation associated with low-level rifampin resistance

Akos Somoskovi et al. J Clin Microbiol. 2013 Sep.

Abstract

Xpert-MTB/Rif is one of the most frequently used molecular screening tests for multidrug-resistant tuberculosis worldwide. We report false-negative assay results in the presence of rpoB Leu533Pro, which is associated with low-level phenotypic rifampin resistance. Accurate and timely confirmation of rifampin susceptibility results obtained with Xpert-MTB/Rif is imperative.

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References

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