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. 2013 Jul 4:(77):e4367.
doi: 10.3791/4367.

The resident-intruder paradigm: a standardized test for aggression, violence and social stress

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The resident-intruder paradigm: a standardized test for aggression, violence and social stress

Jaap M Koolhaas et al. J Vis Exp. .

Abstract

This video publication explains in detail the experimental protocol of the resident-intruder paradigm in rats. This test is a standardized method to measure offensive aggression and defensive behavior in a semi natural setting. The most important behavioral elements performed by the resident and the intruder are demonstrated in the video and illustrated using artistic drawings. The use of the resident intruder paradigm for acute and chronic social stress experiments is explained as well. Finally, some brief tests and criteria are presented to distinguish aggression from its more violent and pathological forms.

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References

    1. Albert DJ, Dyson EM, Walsh ML, Petrovic DM. Cohabitation with a female activates testosterone-dependent social aggression in male rats independently of changes in serum testosterone concentration. Physiology & Behavior. 1988;44(6):735–740. - PubMed
    1. Barnett SA. An analysis of social behaviour in wild rats. Proceedings of the Zoological Society London. 1958;130:107.
    1. Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. (New York, N.Y.) 2006;311(5762):864–868. - PubMed
    1. Blanchard RJ, Blanchard DC, Takahashi T, Kelley MJ. Attack and defensive behaviour in the albino rat. Animal Behaviour. 1977;25(3):622–634. - PubMed
    1. Blanchard RJ, Wall PM, Blanchard DC. Problems in the study of rodent aggression. Hormones and Behavior. 2003;44(3):161–170. - PubMed

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