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. 2013 Jun;7(3):338-48.
doi: 10.1109/TBCAS.2012.2203597.

CMOS neurotransmitter microarray: 96-channel integrated potentiostat with on-die microsensors

Meisam Honarvar Nazari  1 , Hamed Mazhab-Jafari, Lian Leng, Axel Guenther, Roman Genov
Affiliations

CMOS neurotransmitter microarray: 96-channel integrated potentiostat with on-die microsensors

Meisam Honarvar Nazari et al. IEEE Trans Biomed Circuits Syst. 2013 Jun.

Abstract

A 8 × 12 array of integrated potentiostats for on-CMOS neurotransmitter imaging is presented. Each potentiostat channel measures bidirectional redox currents proportional to the concentration of a neurochemical. By combining the current-to-frequency and the single-slope analog-to-digital converter (ADC) architectures a total linear dynamic range of 95 dB is achieved. A 3.8 mm × 3.1 mm prototype fabricated in a 0.35 μm standard CMOS technology was integrated with flat and 3D on-die gold microelectrodes and an on-chip microfluidic network. It is experimentally validated in in-situ recording of neurotransmitter dopamine.

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