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Review
. 2013;11(6):e1001594.
doi: 10.1371/journal.pbio.1001594. Epub 2013 Jun 25.

More paths to PI3Kγ

Len Stephens  1 , Phillip Hawkins
Affiliations
Review

More paths to PI3Kγ

Len Stephens et al. PLoS Biol. 2013.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Mast cell environment regulates PI3Kγ activation.
Coincident with migration and adhesion of mast cells, adaptor protein p84 relays the GPCR signal from GPCR-mediated dissociation of trimeric G proteins to activate the PI3Kγ complex. However, when mast cells degranulate, FcεRI receptors are clustered via IgE/antigen complexes, and a signaling cascade triggers intracellular Ca2+ store depletion and the opening of store-operated Ca2+ channels. The resulting increase in calcium ion concentration and PLCγ-derived diacylglycerol activates PKCβ, which binds to p110γ and subsequently phosphorylates Ser582. This phosphorylated p110γ can no longer interact with p84, and the PI3Kγ complex is therefore unresponsive to GPCR inputs. Image credit: Walser et al., 10.1371/journal.pbio.1001587
See this image and copyright information in PMC

References

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