Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Aug;28 Suppl 1(0 1):93-8.
doi: 10.1111/jgh.12020.

Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis

Jan Petrasek  1 , Timea Csak, Michal Ganz, Gyongyi Szabo
Affiliations
Review

Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis

Jan Petrasek et al. J Gastroenterol Hepatol. 2013 Aug.

Abstract

The similar histopathological characteristics of alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH), and the crucial role of the innate immune response in both conditions may lead to the assumption that ASH and NASH represent the same pathophysiological entities caused by different risk factors. In this review paper, we elaborate on the pathophysiological differences between these two entities and highlight the disease-specific involvement of signaling molecules downstream of the Toll-like receptor 4, and the differential mechanism by which the inflammasome contributes to ASH versus NASH. Our findings emphasize that ASH and NASH have disease-specific mechanisms and therefore represent distinct biological entities. Further studies are needed to dissect the emerging differences in pathogenesis of these two conditions.

Keywords: Kupffer cells; Toll-like receptors; alcoholic liver disease; alcoholic steatohepatitis; inflammasome; innate immunity; interleukin-1 beta; interleukin-1 receptor antagonist; non-alcoholic steatohepatitis.

PubMed Disclaimer

References

    1. Minino AM, Heron MP, Murphy SL, Kochanek KD, Centers for Disease Control and Prevention National Center for Health Statistics National Vital Statistics System Deaths: Final data for 2004. Natl. Vital Stat. Rep. 2007;55:1–119. - PubMed
    1. Corrao G, Ferrari P, Zambon A, Torchio P, Arico S, Decarli A. Trends of liver cirrhosis mortality in europe, 1970-1989: Age-period-cohort analysis and changing alcohol consumption. Int. J. Epidemiol. 1997;26:100–109. - PubMed
    1. Burroughs A, McNamara D. Liver disease in europe. Aliment. Pharmacol. Ther. 2003;18(Suppl 3):54–59. - PubMed
    1. Kim WR, Brown RS, Jr, Terrault NA, El-Serag H. Burden of liver disease in the united states: Summary of a workshop. Hepatology. 2002;36:227–242. - PubMed
    1. Rehm J, Room R, Graham K, Monteiro M, Gmel G, Sempos CT. The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: An overview. Addiction. 2003;98:1209–1228. - PubMed

Publication types

MeSH terms