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Editorial
. 2013 Aug 1;12(15):2335-6.
doi: 10.4161/cc.25703. Epub 2013 Jul 15.

Ribosome-associated chaperones act as proteostasis sentinels

Janine Kirstein-Miles  1 , Richard I Morimoto
Affiliations
Editorial

Ribosome-associated chaperones act as proteostasis sentinels

Janine Kirstein-Miles et al. Cell Cycle. .
No abstract available

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Figures

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Figure 1. Model of translational control in response to acute and chronic stress by the ribosome-associated chaperone NAC. Acute stress (upper branch) leads to a temporary translational decline due to sequestration of NAC by misfolded and aggregated proteins. Re-balancing of proteostasis by NAC and other molecular chaperones liberates NAC and allows for re-association with ribosomes and translation can resume. Chronic stress (lower branch) such as aging and polyQ expression leads to a terminal sequestration of NAC and, hence, a permanent decrease in protein synthesis.
See this image and copyright information in PMC

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References

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