Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Aug;14(8):663-4.
doi: 10.1038/embor.2013.105. Epub 2013 Jul 16.

Nuclear microbiology--bacterial assault on the nucleolus

Hélène Bierne  1
Affiliations
Comment

Nuclear microbiology--bacterial assault on the nucleolus

Hélène Bierne. EMBO Rep. 2013 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares that she has no conflict of interest.

Figures

Figure 1
Figure 1
Bacterial histone methyltransferases control host gene expression in the nucleus and nucleolus. Legionella, Burkholderia and Chlamydia bacteria residing in cytosolic vacuoles secrete SET-domain-containing effector proteins in the cytosol through type 3 (T3SS; Burkholderia and Chlamydia) or type 4 (T4SS; Legionella) secretion systems. C. trachomatis secretes the nuclear effector (NUE), which targets the nucleus at unknown loci [4]. L. pneumophila secretes a methyltransferase (LpSET) that has been characterized in two ways: (i) in the nucleus, LpSET termed ‘RomA’ trimethylates histone H3 at Lys 14, causing a switch from acetylated to methylated H3K14 at specific gene promoters and thus transcriptional repression [9]; (ii) in the nucleolus, LpSET termed ‘LegAS4’ is proposed to bind to HP1 at rDNA silent promoters and activate transcription by stimulating H3K4 methylation [2]. B. thailandensis secretes a LegAS4-like protein (BtSET) that also activates rDNA transcription in the nucleolus [2]. These mechanisms promote bacterial replication.
See this image and copyright information in PMC

Comment on

References

    1. Bierne H, Cossart P (2012) Cell Microbiol 14: 622–633 - PubMed
    1. Li T et al. (2013) EMBO Rep (In the press)
    1. Bierne H et al. (2012) Cold Spring Harb Perspect Med 2: a010272. - PMC - PubMed
    1. Penini ME et al. (2010) PLoS Pathog 6: e1000995. - PMC - PubMed
    1. Hubber A, Roy CR (2010) Annu Rev Cell Dev Biol 26: 261–283 - PubMed

MeSH terms

Substances

LinkOut - more resources