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. 2013 May-Jun;46(3):373-6.
doi: 10.1590/0037-8682-1202-2013.

Features to validate cerebral toxoplasmosis

Carolina da Cunha Correia  1 , Heloísa Ramos Lacerda Melo, Vláudia Maria Assis Costa, Alessandra Mertens Brainer
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Free article

Features to validate cerebral toxoplasmosis

Carolina da Cunha Correia et al. Rev Soc Bras Med Trop. 2013 May-Jun.
Free article

Abstract

Introduction: Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics.

Methods: We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics.

Results: In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions.

Conclusions: Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii.

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