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. 2013 Nov 11;49(87):10224-6.
doi: 10.1039/c3cc43000f.

Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

Wei Zheng  1 , Qun Luo, Yu Lin, Yao Zhao, Xiuli Wang, Zhifeng Du, Xiang Hao, Yang Yu, Shuang Lü, Liyun Ji, Xianchan Li, Ling Yang, Fuyi Wang
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Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

Wei Zheng et al. Chem Commun (Camb). .

Erratum in

  • Chem Commun (Camb). 2013 Dec 28;49(100):11826

Abstract

The complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.

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