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. 2013 Jun;9(6):1351-7.
doi: 10.4161/hv.24168. Epub 2013 Mar 7.

Persistence clinical studies: can you believe what you see?

Brigitte Cheuvart  1 , Véronique Bianco, Magalie Caubet, Martine Douha, Laurence Fissette, Nancy François, Anne Sumbul
Affiliations

Persistence clinical studies: can you believe what you see?

Brigitte Cheuvart et al. Hum Vaccin Immunother. 2013 Jun.

Abstract

Long-term immunity, evaluated by the persistence of antibody titers, is important to assess duration of protection induced by vaccination. This paper aims at drawing awareness on the risk of misinterpreting persistence results in absence of adjustment for missing or left-censored data. Using simulations, the paper shows that repeated measurement models are an appropriate alternative to control the bias associated to unadjusted persistence results.

Keywords: left-censored data; long-term antibody; missing data; persistence; repeated measurement.

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Figures

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Figure 1. Simulated and derived measurable results for one subject.
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Figure 2. Results of simulations— scenario 1—No missing data.
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Figure 3. Results of simulations—scenario 2— Missing at random .
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Figure 4. Unadjusted and estimated rSBA-MenC GMTs.
See this image and copyright information in PMC

References

    1. Carpenter JR, Kenward MG. Missing data in clinical trials—a practical guide. Available at: http://www.hta.ac.uk/nihrmethodology/reports/1589.pdf (accessed 23 Aug 2011).
    1. Molenberghs G, Kenward MG. Missing Data in Clinical Studies. Chichester: Wiley; 2010.
    1. CHMP Guideline on Missing Data in Confirmatory Clinical Trials, EMA/CPMP/EWP/1776/99, 2010.
    1. Verbeke G, Molenberghs G. Linear mixed models for longitudinal data. New York: Springer; 2000.
    1. Little RJA, Rubin DB. Statistical Analysis with Missing Data. New York: J. Wiley & Sons; 1987.

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