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Review
. 2013 Dec;7(4):356-60.
doi: 10.1007/s12105-013-0452-1. Epub 2013 Jul 16.

Giant peripheral ossifying fibroma: a case report and clinicopathologic review of 10 cases from the literature

Esther L B Childers  1 , Iris Morton, Cheryl E Fryer, Babak Shokrani
Affiliations
Review

Giant peripheral ossifying fibroma: a case report and clinicopathologic review of 10 cases from the literature

Esther L B Childers et al. Head Neck Pathol. 2013 Dec.

Abstract

Peripheral ossifying fibroma (POF) is most often a self-limiting, sessile or pedunculated, gingival nodule that is believed to be a reactive rather than neoplastic pathologic process. The lesion is typically <2cm, however it has been recognized that some examples may grow quite large and may displace teeth. The mass-like clinical presentation and radiographic appearance of soft tissue calcification may lead to misclassification; however the histologic appearance is diagnostic. Giant POFs (GPOF) have been referred to in the literature by several other names (large, atypical, huge, gigantiform). The distinguishing characteristics of GPOFs and the factors that contribute to their growth have primarily been explored through case reports. We present a new case of POF that was giant and review 10 previously reported giant lesions, with focus on the clinical presentation, radiographic features, and outcome to explore the possibility that this represents a distinct clinical subset of lesion, with a unique set of features that warrant recognition for accurate diagnosis.

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Figures

Fig. 1
Fig. 1
Intraoral view revealing an exophytic mass with normal overlying mucosa filling the right anterior mandibular vestibule
Fig. 2
Fig. 2
Occlusal film reveals a poorly defined, facially expansile lesion with the appearance of central radiating opaque spicules and displacement of involved teeth
Fig. 3
Fig. 3
Involved teeth were removed along with soft tissue mass and submitted for histologic examination and definitive diagnosis. Note small base of lesion relative to greatest diameter
Fig. 4
Fig. 4
An area of calcification surrounded by fibrous stroma seen throughout the lesion, typical of peripheral ossifying fibroma. (×20 magnification)
Fig. 5
Fig. 5
Photomicrograph of H and E stain (a), and polarized view (b) showing the mix of woven and lamellar bone typical of the calcified material in the lesion. (×100 magnification)
Fig. 6
Fig. 6
Patient healed post-surgical excision
See this image and copyright information in PMC

References

    1. Buchner A, Shnaiderman-Shapiro A, Vered M. Relative frequency of localized reactive hyperplastic lesions of the gingiva: a retrospective study of 1675 cases from Israel. J Oral Pathol Med. 2010;39(8):631–638. doi: 10.1111/j.1600-0714.2010.00895.x. - DOI - PubMed
    1. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 3rd ed. St. Louis, MO: Saunders Elsevier; 2009. p. 521–2.
    1. Bodner L, Dayan D. Growth potential of peripheral ossifying fibroma. J Clin Periodontol. 1987;14(9):551–554. doi: 10.1111/j.1600-051X.1987.tb00998.x. - DOI - PubMed
    1. Poon CK, Kwan PC, Chao SY. Giant peripheral ossifying fibroma of the maxilla: report of a case. J Oral Maxillofac Surg. 1995;53(6):695–698. doi: 10.1016/0278-2391(95)90174-4. - DOI - PubMed
    1. Kim J, Kim ES. Huge peripheral ossifying fibroma of the lower posterior edentulous ridge. J Korean Assoc Maxillofac Plast Reconstr Surg. 2009;31(5):435–439.

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