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Comment
. 2013 Aug;142(2):97-100.
doi: 10.1085/jgp.201311046. Epub 2013 Jul 15.

What activates inactivation?

Christopher A Ahern  1
Affiliations
Comment

What activates inactivation?

Christopher A Ahern. J Gen Physiol. 2013 Aug.
No abstract available

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Figures

Figure 1.
Figure 1.
The life cycle of sodium channel inactivation. (Top) A simplified model of a voltage-gated sodium channel, with the DI–DIII voltage sensors functionally compartmentalized from DIV and an inactivation “gate” (red bar) that is held in place by the DIV VSD. (Right) The potential contributions of DI–III to activation and the DIV VSD to fast inactivation from the open conformation. DIV S4 activation (bottom right) allows for the inactivation gate to relocate to a pore site, occluding sodium conductance. (Left) SSI proceeds after DIV activation through a series of nonconducting states. The possibility of a single inactivated conformational end point with all VSDs activated is shown at the bottom, consistent with the kinetic scheme in Fig. 6 of Capes et al. (2013) in this issue of the Journal.
See this image and copyright information in PMC

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References

    1. Aldrich R.W., Corey D.P., Stevens C.F. 1983. A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature. 306:436–441 10.1038/306436a0 - DOI - PubMed
    1. Bao H., Hakeem A., Henteleff M., Starkus J.G., Rayner M.D. 1999. Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels. J. Gen. Physiol. 113:139–151 10.1085/jgp.113.1.139 - DOI - PMC - PubMed
    1. Bosmans F., Martin-Eauclaire M.F., Swartz K.J. 2008. Deconstructing voltage sensor function and pharmacology in sodium channels. Nature. 456:202–208 10.1038/nature07473 - DOI - PMC - PubMed
    1. Capes D.L., Arcisio-Miranda M., Jarecki B.W., French R.J., Chanda B. 2012. Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor. Proc. Natl. Acad. Sci. USA. 109:2648–2653 10.1073/pnas.1115575109 - DOI - PMC - PubMed
    1. Capes D.L., Goldschen-Ohm M.P., Arcisio-Miranda M., Bezanilla F., Chanda B. 2013. Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels. J. Gen. Physiol. 142:101–112 - PMC - PubMed

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